| Transactions |
| Date | Team | Player | Type | OthTm | EffDate | When |
| 6/7/2008 | ALX | Aardsma | Demoted to reserve roster | | | Before |
| 6/7/2008 | ALX | Sarfate | Promoted to active roster | | | Before |
| 6/7/2008 | RCH | Carrasco | Signed | | | Before |
| 6/7/2008 | RCH | Carrasco | Demoted to reserve roster | | | Before |
| 6/7/2008 | RCH | Carrasco | Promoted to active roster | | | Before |
| 6/7/2008 | RCH | Percival | Demoted to reserve roster | | | Before |
| 6/7/2008 | RCH | Varitek | Demoted to reserve roster | | | Before |
| 6/7/2008 | RCH | Willis | Released | | | Before |
| 6/7/2008 | RCH | Zaun | Promoted to active roster | | | Before |
| 6/7/2008 | WIC | Aceves | Demoted to reserve roster | | | Before |
| 6/7/2008 | WIC | Veras | Promoted to active roster | | | Before |
| 6/14/2008 | ALX | Figgins | Placed on disabled list | | 6/14/2008 | Before |
| 6/14/2008 | ALX | Hawkins | Promoted to active roster | | | Before |
| 6/14/2008 | ALX | Inge | Promoted to active roster | | | Before |
| 6/14/2008 | ALX | Sarfate | Demoted to reserve roster | | | Before |
| 6/14/2008 | BRO | Bedard | Demoted to reserve roster | | | Before |
| 6/14/2008 | BRO | Buchholz,C | Promoted to active roster | | | Before |
| 6/14/2008 | BRO | Cruz,N | Promoted to active roster | | | Before |
| 6/14/2008 | BRO | Duchscherer | Demoted to reserve roster | | | Before |
| 6/14/2008 | BRO | Jones,Ad | Placed on disabled list | | 6/14/2008 | Before |
| 6/14/2008 | BRO | Ziegler | Promoted to active roster | | | Before |
| 6/14/2008 | RCH | Joyce | Promoted to active roster | | | Before |
| 6/14/2008 | RCH | Lugo | Promoted to active roster | | | Before |
| 6/14/2008 | RCH | Rios | Demoted to reserve roster | | | Before |
| 6/14/2008 | RCH | Wells,V | Demoted to reserve roster | | | Before |
| 6/14/2008 | WIC | Aceves | Promoted to active roster | | | Before |
| 6/14/2008 | WIC | Ramirez,Ed | Demoted to reserve roster | | | Before |
| 6/21/2008 | ALX | Aardsma | Promoted to active roster | | | Before |
| 6/21/2008 | ALX | Hawkins | Demoted to reserve roster | | | Before |
| 6/21/2008 | BRO | Aybar,E | Promoted to active roster | | | Before |
| 6/21/2008 | BRO | Bedard | Promoted to active roster | | | Before |
| 6/21/2008 | BRO | Buchholz,C | Demoted to reserve roster | | | Before |
| 6/21/2008 | BRO | Cash | Promoted to active roster | | | Before |
| 6/21/2008 | BRO | Duchscherer | Promoted to active roster | | | Before |
| 6/21/2008 | BRO | Galarraga | Promoted to active roster | | | Before |
| 6/21/2008 | BRO | Hall,T | Demoted to reserve roster | | | Before |
| 6/21/2008 | BRO | Harden | Demoted to reserve roster | | | Before |
| 6/21/2008 | BRO | Hughes | Promoted to active roster | | | Before |
| 6/21/2008 | BRO | Kendrick,H | Demoted to reserve roster | | | Before |
| 6/21/2008 | BRO | Rhodes | Demoted to reserve roster | | | Before |
| 6/21/2008 | BRO | Verlander | Demoted to reserve roster | | | Before |
| 6/21/2008 | KNG | Braden | Promoted to active roster | | | Before |
| 6/21/2008 | KNG | Greinke | Placed on disabled list | | 6/18/2008 | Before |
| 6/21/2008 | RCH | Lugo | Demoted to reserve roster | | | Before |
| 6/21/2008 | RCH | Wells,V | Promoted to active roster | | | Before |
| 6/21/2008 | WIC | Aceves | Demoted to reserve roster | | | Before |
| 6/21/2008 | WIC | Iwamura | Promoted to active roster | | | Before |
| 6/21/2008 | WIC | Lopez,Ja | Demoted to reserve roster | | | Before |
| 6/21/2008 | WIC | Ramirez,Ed | Promoted to active roster | | | Before |
| 6/21/2008 | WIC | Reyes,D | Promoted to active roster | | | Before |
| 6/21/2008 | WIC | Santiago | Demoted to reserve roster | | | Before |
| 6/27/2008 | AH | Barton,D | Promoted to active roster | | | Before |
| 6/27/2008 | AH | Barton,D | Placed on disabled list | | 6/28/2008 | Before |
| 6/27/2008 | AH | Bradley | Demoted to reserve roster | | | Before |
| 6/27/2008 | AH | Breslow | Demoted to reserve roster | | | Before |
| 6/27/2008 | AH | Breslow | Promoted to active roster | | | Before |
| 6/27/2008 | AH | Bruney | Demoted to reserve roster | | | Before |
| 6/27/2008 | AH | Callaspo | Demoted to reserve roster | | | Before |
| 6/27/2008 | AH | German,E | Promoted to active roster | | | Before |
| 6/27/2008 | AH | Jenks | Demoted to reserve roster | | | Before |
| 6/27/2008 | AH | Jenks | Promoted to active roster | | | Before |
| 6/27/2008 | AH | Littleton | Promoted to active roster | | | Before |
| 6/27/2008 | AH | Moeller | Promoted to active roster | | | Before |
| 6/27/2008 | AH | Reyes,Al | Demoted to reserve roster | | | Before |
| 6/27/2008 | AH | Rodriguez,A | Demoted to reserve roster | | | Before |
| 6/27/2008 | AH | Scott | Promoted to active roster | | | Before |
| 6/27/2008 | AH | Slowey | Demoted to reserve roster | | | Before |
| 6/27/2008 | AH | Wakefield | Demoted to reserve roster | | | Before |
| 6/27/2008 | AH | Washburn | Promoted to active roster | | | Before |
| 6/27/2008 | AH | Wilson,C | Promoted to active roster | | | Before |
| 6/27/2008 | ALX | Eveland | Demoted to reserve roster | | | Before |
| 6/27/2008 | ALX | Outman | Promoted to active roster | | | Before |
| 6/27/2008 | BER | Brown,A | Promoted to active roster | | | Before |
| 6/27/2008 | BER | Carroll,J | Promoted to active roster | | | Before |
| 6/27/2008 | BER | Francisco,B | Demoted to reserve roster | | | Before |
| 6/27/2008 | BER | Lewis,S | Promoted to active roster | | | Before |
| 6/27/2008 | BER | Thornton | Demoted to reserve roster | | | Before |
| 6/27/2008 | BER | Wang | Demoted to reserve roster | | | Before |
| 6/27/2008 | BRO | Bedard | Demoted to reserve roster | | | Before |
| 6/27/2008 | BRO | Buchholz,C | Promoted to active roster | | | Before |
| 6/27/2008 | BRO | Duchscherer | Demoted to reserve roster | | | Before |
| 6/27/2008 | BRO | Harden | Promoted to active roster | | | Before |
| 6/27/2008 | BRO | Hughes | Demoted to reserve roster | | | Before |
| 6/27/2008 | BRO | Lackey | Demoted to reserve roster | | | Before |
| 6/27/2008 | BRO | Lackey | Promoted to active roster | | | Before |
| 6/27/2008 | BRO | Verlander | Promoted to active roster | | | Before |
| 6/27/2008 | KNG | Carlson | Demoted to reserve roster | | | Before |
| 6/27/2008 | KNG | Tejeda,R | Promoted to active roster | | | Before |
| 6/27/2008 | RCH | Joyce | Demoted to reserve roster | | | Before |
| 6/27/2008 | RCH | Mahay | Demoted to reserve roster | | | Before |
| 6/27/2008 | RCH | McGowan | Demoted to reserve roster | | | Before |
| 6/27/2008 | RCH | Pennington | Promoted to active roster | | | Before |
| 6/27/2008 | RCH | Percival | Promoted to active roster | | | Before |
| 6/27/2008 | RCH | Richard | Promoted to active roster | | | Before |
| 6/27/2008 | RCH | Varitek | Promoted to active roster | | | Before |
| 6/27/2008 | RCH | Zaun | Demoted to reserve roster | | | Before |
| 6/27/2008 | WIC | Miner | Promoted to active roster | | | Before |
| 6/27/2008 | WIC | Span | Demoted to reserve roster | | | Before |
| 6/29/2008 | ALX | Figgins | Activated from disabled list | | | Before |
| 6/29/2008 | ALX | Lowell | Demoted to reserve roster | | | Before |
| 7/4/2008 | AH | Bradford | Demoted to reserve roster | | | Before |
| 7/4/2008 | AH | Bradley | Promoted to active roster | | | Before |
| 7/4/2008 | AH | Breslow | Demoted to reserve roster | | | Before |
| 7/4/2008 | AH | Bruney | Demoted to reserve roster | | | Before |
| 7/4/2008 | AH | Bruney | Promoted to active roster | | | Before |
| 7/4/2008 | AH | Callaspo | Demoted to reserve roster | | | Before |
| 7/4/2008 | AH | Callaspo | Promoted to active roster | | | Before |
| 7/4/2008 | AH | Reyes,Al | Demoted to reserve roster | | | Before |
| 7/4/2008 | AH | Reyes,Al | Promoted to active roster | | | Before |
| 7/4/2008 | AH | Rivera,J | Demoted to reserve roster | | | Before |
| 7/4/2008 | AH | Rodriguez,A | Promoted to active roster | | | Before |
| 7/4/2008 | AH | Slowey | Promoted to active roster | | | Before |
| 7/4/2008 | AH | Wakefield | Promoted to active roster | | | Before |
| 7/4/2008 | ALX | Eveland | Promoted to active roster | | | Before |
| 7/4/2008 | ALX | Figgins | Activated from disabled list | | | Before |
| 7/4/2008 | ALX | Lowell | Demoted to reserve roster | | | Before |
| 7/4/2008 | ALX | Outman | Demoted to reserve roster | | | Before |
| 7/4/2008 | BRO | Cruz,N | Demoted to reserve roster | | | Before |
| 7/4/2008 | BRO | Duchscherer | Promoted to active roster | | | Before |
| 7/4/2008 | BRO | Harden | Demoted to reserve roster | | | Before |
| 7/4/2008 | BRO | Jones,Ad | Activated from disabled list | | | Before |
| 7/4/2008 | KNG | Braden | Demoted to reserve roster | | | Before |
| 7/4/2008 | KNG | Greinke | Activated from disabled list | | | Before |
| 7/4/2008 | RCH | Beckett | Placed on disabled list | | 7/4/2008 | Before |
| 7/4/2008 | RCH | Lugo | Promoted to active roster | | | Before |
| 7/4/2008 | RCH | McGowan | Promoted to active roster | | | Before |
| 7/4/2008 | RCH | Pennington | Demoted to reserve roster | | | Before |
| 7/4/2008 | WIC | Gaudin | Promoted to active roster | | | Before |
| 7/4/2008 | WIC | Ramirez,Ed | Demoted to reserve roster | | | Before |
| 7/6/2008 | BER | Lewis,S | Demoted to reserve roster | | | Before |
| 7/11/2008 | AH | Bradford | Promoted to active roster | | | Before |
| 7/11/2008 | AH | Bradley | Demoted to reserve roster | | | Before |
| 7/11/2008 | AH | Breslow | Demoted to reserve roster | | | Before |
| 7/11/2008 | AH | Breslow | Promoted to active roster | | | Before |
| 7/11/2008 | AH | Bruney | Demoted to reserve roster | | | Before |
| 7/11/2008 | AH | Bruney | Promoted to active roster | | | Before |
| 7/11/2008 | AH | Callaspo | Promoted to active roster | | | Before |
| 7/11/2008 | AH | DeJesus | Demoted to reserve roster | | | Before |
| 7/11/2008 | AH | Jenks | Demoted to reserve roster | | | Before |
| 7/11/2008 | AH | Reyes,Al | Promoted to active roster | | | Before |
| 7/11/2008 | AH | Rivera,J | Promoted to active roster | | | Before |
| 7/11/2008 | AH | Youkilis | Demoted to reserve roster | | | Before |
| 7/11/2008 | ALX | Hawkins | Promoted to active roster | | | Before |
| 7/11/2008 | ALX | Sexson | Demoted to reserve roster | | | Before |
| 7/11/2008 | BER | Lewis,S | Released | | | Before |
| 7/11/2008 | BER | Lewis,S | Demoted to reserve roster | | | Before |
| 7/11/2008 | BER | Wang | Promoted to active roster | | | Before |
| 7/11/2008 | BER | Wang | Promoted to active roster | | | Before |
| 7/11/2008 | BRO | Blake | Demoted to reserve roster | | | Before |
| 7/11/2008 | BRO | Hughes | Promoted to active roster | | | Before |
| 7/11/2008 | BRO | Kendrick,H | Promoted to active roster | | | Before |
| 7/11/2008 | BRO | Lackey | Demoted to reserve roster | | | Before |
| 7/11/2008 | RCH | Joyce | Demoted to reserve roster | | | Before |
| 7/11/2008 | RCH | Joyce | Promoted to active roster | | | Before |
| 7/11/2008 | RCH | Mahay | Promoted to active roster | | | Before |
| 7/11/2008 | RCH | Rios | Promoted to active roster | | | Before |
| 7/11/2008 | RCH | Ryan,BJ | Demoted to reserve roster | | | Before |
| 7/11/2008 | RCH | Varitek | Demoted to reserve roster | | | Before |
| 7/11/2008 | RCH | Wells,V | Demoted to reserve roster | | | Before |
| 7/11/2008 | RCH | Zaun | Promoted to active roster | | | Before |
| 7/11/2008 | WIC | Aceves | Promoted to active roster | | | Before |
| 7/11/2008 | WIC | Byrd,M | Demoted to reserve roster | | | Before |
| 7/11/2008 | WIC | Gaudin | Demoted to reserve roster | | | Before |
| 7/11/2008 | WIC | Izturis,M | Demoted to reserve roster | | | Before |
| 7/11/2008 | WIC | Miner | Demoted to reserve roster | | | Before |
| 7/11/2008 | WIC | Ramirez,Ed | Promoted to active roster | | | Before |
| 7/11/2008 | WIC | Santiago | Promoted to active roster | | | Before |
| 7/11/2008 | WIC | Span | Promoted to active roster | | | Before |
| 7/16/2008 | BRO | Reyes,D | Acquired via trade | WIC | | After |
| 7/16/2008 | WIC | Reyes,D | Traded away | BRO | | After |
| 7/17/2008 | AH | Barton,D | Activated from disabled list | | | Before |
| 7/17/2008 | AH | Barton,D | Demoted to reserve roster | | | Before |
| 7/17/2008 | AH | Blackburn | Demoted to reserve roster | | | Before |
| 7/17/2008 | AH | Bradley | Promoted to active roster | | | Before |
| 7/17/2008 | AH | Breslow | Demoted to reserve roster | | | Before |
| 7/17/2008 | AH | Breslow | Promoted to active roster | | | Before |
| 7/17/2008 | AH | Bruney | Demoted to reserve roster | | | Before |
| 7/17/2008 | AH | Bruney | Promoted to active roster | | | Before |
| 7/17/2008 | AH | DeJesus | Promoted to active roster | | | Before |
| 7/17/2008 | AH | Jenks | Demoted to reserve roster | | | Before |
| 7/17/2008 | AH | Jenks | Promoted to active roster | | | Before |
| 7/17/2008 | AH | Reyes,Al | Demoted to reserve roster | | | Before |
| 7/17/2008 | AH | Rivera,J | Demoted to reserve roster | | | Before |
| 7/17/2008 | AH | Youkilis | Promoted to active roster | | | Before |
| 7/17/2008 | ALX | Drew,J | Demoted to reserve roster | | | Before |
| 7/17/2008 | ALX | Drew,J | Promoted to active roster | | | Before |
| 7/17/2008 | ALX | Drew,J | Demoted to reserve roster | | | Before |
| 7/17/2008 | ALX | Lowell | Promoted to active roster | | | Before |
| 7/17/2008 | ALX | Posada | Demoted to reserve roster | | | Before |
| 7/17/2008 | ALX | Sexson | Promoted to active roster | | | Before |
| 7/17/2008 | BRO | Aybar,E | Demoted to reserve roster | | | Before |
| 7/17/2008 | BRO | Bedard | Promoted to active roster | | | Before |
| 7/17/2008 | BRO | Blake | Promoted to active roster | | | Before |
| 7/17/2008 | BRO | Buchholz,C | Demoted to reserve roster | | | Before |
| 7/17/2008 | BRO | Cruz,N | Demoted to reserve roster | | | Before |
| 7/17/2008 | BRO | Cruz,N | Promoted to active roster | | | Before |
| 7/17/2008 | BRO | Ellsbury | Demoted to reserve roster | | | Before |
| 7/17/2008 | BRO | Ellsbury | Promoted to active roster | | | Before |
| 7/17/2008 | BRO | Galarraga | Demoted to reserve roster | | | Before |
| 7/17/2008 | BRO | Harden | Promoted to active roster | | | Before |
| 7/17/2008 | BRO | Hughes | Demoted to reserve roster | | | Before |
| 7/17/2008 | BRO | Lackey | Promoted to active roster | | | Before |
| 7/17/2008 | BRO | Rhodes | Released | | | Before |
| 7/17/2008 | BRO | Verlander | Demoted to reserve roster | | | Before |
| 7/17/2008 | KNG | Carlson | Promoted to active roster | | | Before |
| 7/17/2008 | KNG | Crain | Demoted to reserve roster | | | Before |
| 7/17/2008 | KNG | Quentin | Placed on disabled list | | 7/16/2008 | Before |
| 7/17/2008 | KNG | Wood,B | Promoted to active roster | | | Before |
| 7/17/2008 | RCH | Camp | Signed | | | Before |
| 7/17/2008 | RCH | Camp | Promoted to active roster | | | Before |
| 7/17/2008 | RCH | Everett | Signed | | | Before |
| 7/17/2008 | RCH | Everett | Promoted to active roster | | | Before |
| 7/17/2008 | RCH | Feldman | Signed | | | Before |
| 7/17/2008 | RCH | Feldman | Promoted to active roster | | | Before |
| 7/17/2008 | RCH | Lugo | Released | | | Before |
| 7/17/2008 | RCH | Mahay | Released | | | Before |
| 7/17/2008 | RCH | McGowan | Placed on disabled list | | 7/13/2008 | Before |
| 7/17/2008 | RCH | Meche | Demoted to reserve roster | | | Before |
| 7/17/2008 | RCH | Ryan,BJ | Promoted to active roster | | | Before |
| 7/17/2008 | RCH | Varitek | Released | | | Before |
| 7/17/2008 | WIC | Aceves | Demoted to reserve roster | | | Before |
| 7/17/2008 | WIC | Byrd,M | Promoted to active roster | | | Before |
| 7/17/2008 | WIC | Izturis,M | Promoted to active roster | | | Before |
| 7/17/2008 | WIC | Lopez,Ja | Promoted to active roster | | | Before |
| 7/17/2008 | WIC | Santiago | Demoted to reserve roster | | | Before |
| 7/22/2008 | RCH | Beckett | Activated from disabled list | | | Before |
| 7/22/2008 | RCH | Richard | Demoted to reserve roster | | | Before |
| 7/24/2008 | AH | Barton,D | Demoted to reserve roster | | | Before |
| 7/24/2008 | AH | Barton,D | Promoted to active roster | | | Before |
| 7/24/2008 | AH | Barton,D | Promoted to active roster | | | Before |
| 7/24/2008 | AH | Blackburn | Promoted to active roster | | | Before |
| 7/24/2008 | AH | Bradford | Demoted to reserve roster | | | Before |
| 7/24/2008 | AH | Bradley | Demoted to reserve roster | | | Before |
| 7/24/2008 | AH | Breslow | Demoted to reserve roster | | | Before |
| 7/24/2008 | AH | Breslow | Promoted to active roster | | | Before |
| 7/24/2008 | AH | Breslow | Promoted to active roster | | | Before |
| 7/24/2008 | AH | Bruney | Demoted to reserve roster | | | Before |
| 7/24/2008 | AH | Bruney | Promoted to active roster | | | Before |
| 7/24/2008 | AH | Bruney | Demoted to reserve roster | | | Before |
| 7/24/2008 | AH | Bruney | Promoted to active roster | | | Before |
| 7/24/2008 | AH | Callaspo | Demoted to reserve roster | | | Before |
| 7/24/2008 | AH | Jenks | Promoted to active roster | | | Before |
| 7/24/2008 | AH | Reyes,Al | Demoted to reserve roster | | | Before |
| 7/24/2008 | AH | Reyes,Al | Promoted to active roster | | | Before |
| 7/24/2008 | AH | Rivera,J | Demoted to reserve roster | | | Before |
| 7/24/2008 | AH | Rivera,J | Promoted to active roster | | | Before |
| 7/24/2008 | AH | Slowey | Demoted to reserve roster | | | Before |
| 7/24/2008 | ALX | Delcarmen | Demoted to reserve roster | | | Before |
| 7/24/2008 | ALX | Delcarmen | Promoted to active roster | | | Before |
| 7/24/2008 | ALX | Drew,J | Promoted to active roster | | | Before |
| 7/24/2008 | ALX | Lowell | Demoted to reserve roster | | | Before |
| 7/24/2008 | ALX | Martinez | Demoted to reserve roster | | | Before |
| 7/24/2008 | ALX | Posada | Promoted to active roster | | | Before |
| 7/24/2008 | BER | Corcoran | Promoted to active roster | | | Before |
| 7/24/2008 | BER | Francisco,B | Promoted to active roster | | | Before |
| 7/24/2008 | BER | Johnson,Ji | Promoted to active roster | | | Before |
| 7/24/2008 | BER | Putz | Demoted to reserve roster | | | Before |
| 7/24/2008 | BER | Thames | Demoted to reserve roster | | | Before |
| 7/24/2008 | BER | Wang | Demoted to reserve roster | | | Before |
| 7/24/2008 | BRO | Aybar,E | Promoted to active roster | | | Before |
| 7/24/2008 | BRO | Bedard | Demoted to reserve roster | | | Before |
| 7/24/2008 | BRO | Buchholz,C | Promoted to active roster | | | Before |
| 7/24/2008 | BRO | Cruz,N | Promoted to active roster | | | Before |
| 7/24/2008 | BRO | Galarraga | Promoted to active roster | | | Before |
| 7/24/2008 | BRO | Giambi | Demoted to reserve roster | | | Before |
| 7/24/2008 | BRO | Kendrick,H | Demoted to reserve roster | | | Before |
| 7/24/2008 | BRO | Lackey | Demoted to reserve roster | | | Before |
| 7/24/2008 | BRO | Reyes,D | Demoted to reserve roster | | | Before |
| 7/24/2008 | BRO | Verlander | Promoted to active roster | | | Before |
| 7/24/2008 | EVN | Bloomquist | Promoted to active roster | | | Before |
| 7/24/2008 | EVN | Crede | Promoted to active roster | | | Before |
| 7/24/2008 | EVN | Frasor | Demoted to reserve roster | | | Before |
| 7/24/2008 | EVN | Hill,A | Demoted to reserve roster | | | Before |
| 7/24/2008 | KNG | Blanton | Demoted to reserve roster | | | Before |
| 7/24/2008 | KNG | Braden | Promoted to active roster | | | Before |
| 7/24/2008 | KNG | Gonzalez,G | Promoted to active roster | | | Before |
| 7/24/2008 | KNG | Miller,T | Demoted to reserve roster | | | Before |
| 7/24/2008 | RCH | Pennington | Promoted to active roster | | | Before |
| 7/24/2008 | RCH | Percival | Demoted to reserve roster | | | Before |
| 7/24/2008 | RCH | Punto | Demoted to reserve roster | | | Before |
| 7/24/2008 | RCH | Rhodes | Signed | | | Before |
| 7/24/2008 | RCH | Rhodes | Promoted to active roster | | | Before |
| 7/24/2008 | RCH | Richard | Released | | | Before |
| 7/24/2008 | WIC | Aceves | Promoted to active roster | | | Before |
| 7/24/2008 | WIC | Veras | Demoted to reserve roster | | | Before |
| 7/29/2008 | KNG | Blalock | Acquired via trade | RCH | | After |
| 7/29/2008 | KNG | Hafner | Traded away | RCH | | After |
| 7/29/2008 | KNG | Ramirez,Man | Acquired via trade | RCH | | After |
| 7/29/2008 | RCH | Blalock | Traded away | KNG | | After |
| 7/29/2008 | RCH | Hafner | Acquired via trade | KNG | | After |
| 7/29/2008 | RCH | Ramirez,Man | Traded away | KNG | | After |
| 7/31/2008 | AH | Barton,D | Demoted to reserve roster | | | Before |
| 7/31/2008 | AH | Bradford | Demoted to reserve roster | | | Before |
| 7/31/2008 | AH | Bradford | Promoted to active roster | | | Before |
| 7/31/2008 | AH | Bradley | Promoted to active roster | | | Before |
| 7/31/2008 | AH | Bruney | Promoted to active roster | | | Before |
| 7/31/2008 | AH | Callaspo | Demoted to reserve roster | | | Before |
| 7/31/2008 | AH | Callaspo | Promoted to active roster | | | Before |
| 7/31/2008 | AH | Littleton | Demoted to reserve roster | | | Before |
| 7/31/2008 | AH | Millwood | Demoted to reserve roster | | | Before |
| 7/31/2008 | AH | Reyes,Al | Demoted to reserve roster | | | Before |
| 7/31/2008 | AH | Reyes,Al | Promoted to active roster | | | Before |
| 7/31/2008 | AH | Rivera,J | Demoted to reserve roster | | | Before |
| 7/31/2008 | AH | Rivera,J | Promoted to active roster | | | Before |
| 7/31/2008 | AH | Slowey | Promoted to active roster | | | Before |
| 7/31/2008 | AH | Wilson,C | Demoted to reserve roster | | | Before |
| 7/31/2008 | AH | Wilson,C | Promoted to active roster | | | Before |
| 7/31/2008 | ALX | Aardsma | Demoted to reserve roster | | | Before |
| 7/31/2008 | ALX | Martinez | Promoted to active roster | | | Before |
| 7/31/2008 | ALX | Posada | Demoted to reserve roster | | | Before |
| 7/31/2008 | ALX | Sarfate | Promoted to active roster | | | Before |
| 7/31/2008 | BRO | Bedard | Promoted to active roster | | | Before |
| 7/31/2008 | BRO | Cash | Demoted to reserve roster | | | Before |
| 7/31/2008 | BRO | Cruz,N | Demoted to reserve roster | | | Before |
| 7/31/2008 | BRO | Duchscherer | Demoted to reserve roster | | | Before |
| 7/31/2008 | BRO | Galarraga | Demoted to reserve roster | | | Before |
| 7/31/2008 | BRO | Hall,T | Promoted to active roster | | | Before |
| 7/31/2008 | BRO | Harden | Demoted to reserve roster | | | Before |
| 7/31/2008 | BRO | Hughes | Promoted to active roster | | | Before |
| 7/31/2008 | BRO | Kendrick,H | Promoted to active roster | | | Before |
| 7/31/2008 | BRO | Lackey | Promoted to active roster | | | Before |
| 7/31/2008 | KNG | Balfour | Demoted to reserve roster | | | Before |
| 7/31/2008 | KNG | Blalock | Promoted to active roster | | | Before |
| 7/31/2008 | KNG | Blanton | Demoted to reserve roster | | | Before |
| 7/31/2008 | KNG | Blanton | Promoted to active roster | | | Before |
| 7/31/2008 | KNG | Buck,J | Released | | | Before |
| 7/31/2008 | KNG | Crain | Promoted to active roster | | | Before |
| 7/31/2008 | KNG | Garko | Demoted to reserve roster | | | Before |
| 7/31/2008 | KNG | Gonzalez,G | Demoted to reserve roster | | | Before |
| 7/31/2008 | KNG | Kubel | Demoted to reserve roster | | | Before |
| 7/31/2008 | KNG | Lowrie | Demoted to reserve roster | | | Before |
| 7/31/2008 | KNG | Miller,T | Promoted to active roster | | | Before |
| 7/31/2008 | KNG | Quentin | Activated from disabled list | | | Before |
| 7/31/2008 | KNG | Ramirez,Man | Demoted to reserve roster | | | Before |
| 7/31/2008 | KNG | Ramirez,Man | Promoted to active roster | | | Before |
| 7/31/2008 | RCH | Hafner | Promoted to active roster | | | Before |
| 7/31/2008 | RCH | Joyce | Demoted to reserve roster | | | Before |
| 7/31/2008 | RCH | Joyce | Promoted to active roster | | | Before |
| 7/31/2008 | RCH | Lind | Demoted to reserve roster | | | Before |
| 7/31/2008 | RCH | Marcum | Demoted to reserve roster | | | Before |
| 7/31/2008 | RCH | McGowan | Activated from disabled list | | | Before |
| 7/31/2008 | RCH | Monroe | Signed | | | Before |
| 7/31/2008 | RCH | Monroe | Promoted to active roster | | | Before |
| 7/31/2008 | RCH | Percival | Promoted to active roster | | | Before |
| 7/31/2008 | RCH | Riggans | Signed | | | Before |
| 7/31/2008 | RCH | Riggans | Promoted to active roster | | | Before |
| 7/31/2008 | RCH | Ryan,BJ | Released | | | Before |
| 7/31/2008 | RCH | Zaun | Placed on disabled list | | 7/29/2008 | Before |
| 7/31/2008 | WIC | Aceves | Demoted to reserve roster | | | Before |
| 7/31/2008 | WIC | Santiago | Promoted to active roster | | | Before |
| 7/31/2008 | WIC | Span | Demoted to reserve roster | | | Before |
| 7/31/2008 | WIC | Veras | Promoted to active roster | | | Before |
| 8/6/2008 | AH | Barton,D | Demoted to reserve roster | | | Before |
| 8/6/2008 | AH | Barton,D | Promoted to active roster | | | Before |
| 8/6/2008 | AH | Barton,D | Promoted to active roster | | | Before |
| 8/6/2008 | AH | Blackburn | Demoted to reserve roster | | | Before |
| 8/6/2008 | AH | Blackburn | Promoted to active roster | | | Before |
| 8/6/2008 | AH | Bradford | Promoted to active roster | | | Before |
| 8/6/2008 | AH | Breslow | Demoted to reserve roster | | | Before |
| 8/6/2008 | AH | Bruney | Demoted to reserve roster | | | Before |
| 8/6/2008 | AH | Callaspo | Demoted to reserve roster | | | Before |
| 8/6/2008 | AH | Callaspo | Promoted to active roster | | | Before |
| 8/6/2008 | AH | Littleton | Demoted to reserve roster | | | Before |
| 8/6/2008 | AH | Littleton | Promoted to active roster | | | Before |
| 8/6/2008 | AH | Millwood | Demoted to reserve roster | | | Before |
| 8/6/2008 | AH | Millwood | Promoted to active roster | | | Before |
| 8/6/2008 | AH | Millwood | Promoted to active roster | | | Before |
| 8/6/2008 | AH | Reyes,Al | Promoted to active roster | | | Before |
| 8/6/2008 | AH | Rivera,J | Promoted to active roster | | | Before |
| 8/6/2008 | AH | Rodriguez,A | Demoted to reserve roster | | | Before |
| 8/6/2008 | AH | Slowey | Demoted to reserve roster | | | Before |
| 8/6/2008 | AH | Youkilis | Demoted to reserve roster | | | Before |
| 8/6/2008 | ALX | Choo | Demoted to reserve roster | | | Before |
| 8/6/2008 | ALX | Ozuna | Demoted to reserve roster | | | Before |
| 8/6/2008 | ALX | Ozuna | Promoted to active roster | | | Before |
| 8/6/2008 | ALX | Wise,D | Promoted to active roster | | | Before |
| 8/6/2008 | BRO | Bedard | Demoted to reserve roster | | | Before |
| 8/6/2008 | BRO | Buchholz,C | Demoted to reserve roster | | | Before |
| 8/6/2008 | BRO | Duchscherer | Promoted to active roster | | | Before |
| 8/6/2008 | BRO | Galarraga | Promoted to active roster | | | Before |
| 8/6/2008 | BRO | Hughes | Demoted to reserve roster | | | Before |
| 8/6/2008 | BRO | Reyes,D | Promoted to active roster | | | Before |
| 8/6/2008 | EVN | Davis,C | Demoted to reserve roster | | | Before |
| 8/6/2008 | EVN | Hinske | Promoted to active roster | | | Before |
| 8/6/2008 | KNG | Balfour | Promoted to active roster | | | Before |
| 8/6/2008 | KNG | Blanton | Promoted to active roster | | | Before |
| 8/6/2008 | KNG | Braden | Demoted to reserve roster | | | Before |
| 8/6/2008 | KNG | Crain | Demoted to reserve roster | | | Before |
| 8/6/2008 | KNG | Cuddyer | Demoted to reserve roster | | | Before |
| 8/6/2008 | KNG | Gonzalez,G | Promoted to active roster | | | Before |
| 8/6/2008 | KNG | Lowrie | Promoted to active roster | | | Before |
| 8/6/2008 | KNG | Miller,T | Demoted to reserve roster | | | Before |
| 8/6/2008 | KNG | Rodriguez,S | Demoted to reserve roster | | | Before |
| 8/6/2008 | KNG | Rodriguez,S | Promoted to active roster | | | Before |
| 8/6/2008 | RCH | Marcum | Promoted to active roster | | | Before |
| 8/6/2008 | RCH | Matsuzaka | Demoted to reserve roster | | | Before |
| 8/6/2008 | RCH | Pennington | Demoted to reserve roster | | | Before |
| 8/6/2008 | RCH | Punto | Promoted to active roster | | | Before |
| 8/6/2008 | WIC | Jackson,E | Demoted to reserve roster | | | Before |
| 8/6/2008 | WIC | Westbrook | Promoted to active roster | | | Before |
| 8/8/2008 | ALX | Baker,S | Placed on disabled list | | 8/9/2008 | Before |
| 8/8/2008 | ALX | Ozuna | Promoted to active roster | | | Before |
| 8/8/2008 | ALX | Zobrist | Demoted to reserve roster | | | Before |
| 8/12/2008 | BER | Arredondo | Demoted to reserve roster | | | Before |
| 8/12/2008 | BER | Betancourt,R | Demoted to reserve roster | | | Before |
| 8/12/2008 | BER | Boggs,B | Released | | | Before |
| 8/12/2008 | BER | Garland | Signed | | | Before |
| 8/12/2008 | BER | Liriano | Demoted to reserve roster | | | Before |
| 8/12/2008 | BER | Norton | Released | | | Before |
| 8/12/2008 | BER | Padilla | Signed | | | Before |
| 8/12/2008 | BER | Thornton | Promoted to active roster | | | Before |
| 8/12/2008 | RCH | Devine | Demoted to reserve roster | | | Before |
| 8/12/2008 | RCH | Giese | Signed | | | Before |
| 8/12/2008 | RCH | Joyce | Promoted to active roster | | | Before |
| 8/12/2008 | RCH | Linebrink | Signed | | | Before |
| 8/12/2008 | RCH | Marcum | Demoted to reserve roster | | | Before |
| 8/12/2008 | RCH | Matsuzaka | Promoted to active roster | | | Before |
| 8/12/2008 | RCH | Monroe | Released | | | Before |
| 8/12/2008 | RCH | Percival | Released | | | Before |
| 8/12/2008 | RCH | Rhodes | Released | | | Before |
| 8/12/2008 | RCH | Sweeney,R | Demoted to reserve roster | | | Before |
| 8/12/2008 | RCH | Wells,V | Promoted to active roster | | | Before |
| 8/12/2008 | RCH | Wolfe | Signed | | | Before |
| 8/13/2008 | AH | Blackburn | Demoted to reserve roster | | | Before |
| 8/13/2008 | AH | Bradford | Demoted to reserve roster | | | Before |
| 8/13/2008 | AH | Breslow | Promoted to active roster | | | Before |
| 8/13/2008 | AH | Bruney | Demoted to reserve roster | | | Before |
| 8/13/2008 | AH | Bruney | Promoted to active roster | | | Before |
| 8/13/2008 | AH | Callaspo | Promoted to active roster | | | Before |
| 8/13/2008 | AH | DeJesus | Demoted to reserve roster | | | Before |
| 8/13/2008 | AH | Littleton | Promoted to active roster | | | Before |
| 8/13/2008 | AH | Pedroia | Demoted to reserve roster | | | Before |
| 8/13/2008 | AH | Rodriguez,A | Demoted to reserve roster | | | Before |
| 8/13/2008 | AH | Rodriguez,A | Promoted to active roster | | | Before |
| 8/13/2008 | AH | Slowey | Demoted to reserve roster | | | Before |
| 8/13/2008 | AH | Slowey | Promoted to active roster | | | Before |
| 8/13/2008 | AH | Youkilis | Promoted to active roster | | | Before |
| 8/13/2008 | ALX | Aardsma | Promoted to active roster | | | Before |
| 8/13/2008 | ALX | Oliver | Demoted to reserve roster | | | Before |
| 8/13/2008 | ALX | Raburn | Promoted to active roster | | | Before |
| 8/13/2008 | EVN | Crede | Demoted to reserve roster | | | Before |
| 8/13/2008 | EVN | Crede | Promoted to active roster | | | Before |
| 8/13/2008 | EVN | Crede | Demoted to reserve roster | | | Before |
| 8/13/2008 | EVN | Davis,C | Promoted to active roster | | | Before |
| 8/13/2008 | KNG | Blanton | Placed on disabled list | | 8/7/2008 | Before |
| 8/13/2008 | KNG | Braden | Promoted to active roster | | | Before |
| 8/13/2008 | WIC | Iwamura | Demoted to reserve roster | | | Before |
| 8/13/2008 | WIC | Litsch | Promoted to active roster | | | Before |
| 8/13/2008 | WIC | Span | Promoted to active roster | | | Before |
| 8/13/2008 | WIC | Westbrook | Placed on disabled list | | 8/6/2008 | Before |
| 8/14/2008 | RCH | Riggans | Demoted to reserve roster | | | Before |
| 8/14/2008 | RCH | Zaun | Activated from disabled list | | | Before |
| 8/15/2008 | BER | Betancourt,R | Promoted to active roster | | | Before |
| 8/15/2008 | BER | Brown,A | Demoted to reserve roster | | | Before |
| 8/15/2008 | BER | Nathan | Demoted to reserve roster | | | Before |
| 8/15/2008 | BER | Putz | Promoted to active roster | | | Before |
| 8/20/2008 | ALX | Lowell | Promoted to active roster | | | Before |
| 8/20/2008 | ALX | Matsui,H | Demoted to reserve roster | | | Before |
| 8/20/2008 | ALX | Okajima | Demoted to reserve roster | | | Before |
| 8/20/2008 | BER | Betancourt,R | Promoted to active roster | | | Before |
| 8/20/2008 | BER | Brown,A | Demoted to reserve roster | | | Before |
| 8/20/2008 | BRO | Buchholz,C | Promoted to active roster | | | Before |
| 8/20/2008 | BRO | Duchscherer | Demoted to reserve roster | | | Before |
| 8/20/2008 | BRO | Giambi | Promoted to active roster | | | Before |
| 8/20/2008 | BRO | Hughes | Promoted to active roster | | | Before |
| 8/20/2008 | BRO | Kendrick,H | Demoted to reserve roster | | | Before |
| 8/20/2008 | BRO | Soria | Demoted to reserve roster | | | Before |
| 8/20/2008 | EVN | Cintron | Signed | | | Before |
| 8/20/2008 | EVN | Cintron | Demoted to reserve roster | | | Before |
| 8/20/2008 | EVN | Cintron | Promoted to active roster | | | Before |
| 8/20/2008 | EVN | Rodney | Released | | | Before |
| 8/20/2008 | EVN | Vazquez,R | Demoted to reserve roster | | | Before |
| 8/20/2008 | KNG | Aviles | Demoted to reserve roster | | | Before |
| 8/20/2008 | KNG | Balfour | Demoted to reserve roster | | | Before |
| 8/20/2008 | KNG | Braden | Demoted to reserve roster | | | Before |
| 8/20/2008 | KNG | Crain | Released | | | Before |
| 8/20/2008 | KNG | Davies | Signed | | | Before |
| 8/20/2008 | KNG | Davies | Demoted to reserve roster | | | Before |
| 8/20/2008 | KNG | Davies | Promoted to active roster | | | Before |
| 8/20/2008 | KNG | Garko | Promoted to active roster | | | Before |
| 8/20/2008 | KNG | Kubel | Promoted to active roster | | | Before |
| 8/20/2008 | KNG | Ramirez,Al | Demoted to reserve roster | | | Before |
| 8/20/2008 | KNG | Rodriguez,S | Promoted to active roster | | | Before |
| 8/20/2008 | RCH | Beckett | Demoted to reserve roster | | | Before |
| 8/20/2008 | RCH | Camp | Demoted to reserve roster | | | Before |
| 8/20/2008 | RCH | Devine | Promoted to active roster | | | Before |
| 8/20/2008 | RCH | Hernandez,Fel | Demoted to reserve roster | | | Before |
| 8/20/2008 | RCH | Hernandez,Fel | Promoted to active roster | | | Before |
| 8/20/2008 | RCH | Meche | Promoted to active roster | | | Before |
| 8/20/2008 | WIC | Iwamura | Promoted to active roster | | | Before |
| 8/20/2008 | WIC | Miner | Promoted to active roster | | | Before |
| 8/20/2008 | WIC | Ramirez,Ed | Demoted to reserve roster | | | Before |
| 8/20/2008 | WIC | Santiago | Demoted to reserve roster | | | Before |
| 8/20/2008 | WIC | Santiago | Promoted to active roster | | | Before |
| 8/20/2008 | WIC | Span | Demoted to reserve roster | | | Before |
| 8/26/2008 | ALX | Inglett | Signed | | | Before |
| 8/26/2008 | ALX | Ozuna | Released | | | Before |
| 8/26/2008 | BRO | Bedard | Promoted to active roster | | | Before |
| 8/26/2008 | BRO | Cash | Promoted to active roster | | | Before |
| 8/26/2008 | BRO | Cruz,N | Promoted to active roster | | | Before |
| 8/26/2008 | BRO | Duchscherer | Promoted to active roster | | | Before |
| 8/26/2008 | BRO | Harden | Promoted to active roster | | | Before |
| 8/26/2008 | BRO | Kendrick,H | Promoted to active roster | | | Before |
| 8/26/2008 | BRO | Soria | Promoted to active roster | | | Before |
| 8/26/2008 | EVN | Casilla,A | Signed | | | Before |
| 8/26/2008 | EVN | Cintron | Released | | | Before |
| 8/26/2008 | EVN | Crede | Promoted to active roster | | | Before |
| 8/26/2008 | EVN | Frasor | Promoted to active roster | | | Before |
| 8/26/2008 | EVN | Gardner,B | Released | | | Before |
| 8/26/2008 | EVN | Hill,A | Promoted to active roster | | | Before |
| 8/26/2008 | EVN | League | Promoted to active roster | | | Before |
| 8/26/2008 | EVN | Murphy,Dav | Promoted to active roster | | | Before |
| 8/26/2008 | EVN | Varitek | Signed | | | Before |
| 8/26/2008 | EVN | Vazquez,R | Promoted to active roster | | | Before |
| 8/26/2008 | KNG | Blanton | Activated from disabled list | | | Before |
| 8/26/2008 | KNG | Braden | Promoted to active roster | | | Before |
| 8/26/2008 | KNG | Carlson | Demoted to reserve roster | | | Before |
| 8/26/2008 | KNG | Cuddyer | Promoted to active roster | | | Before |
| 8/26/2008 | KNG | Miller,T | Promoted to active roster | | | Before |
| 8/26/2008 | KNG | Napoli | Demoted to reserve roster | | | Before |
| 8/26/2008 | KNG | Tejeda,R | Demoted to reserve roster | | | Before |
| 8/26/2008 | RCH | Beckett | Promoted to active roster | | | Before |
| 8/26/2008 | RCH | Camp | Promoted to active roster | | | Before |
| 8/26/2008 | RCH | Eckstein | Signed | | | Before |
| 8/26/2008 | RCH | Lind | Promoted to active roster | | | Before |
| 8/26/2008 | RCH | Marcum | Promoted to active roster | | | Before |
| 8/26/2008 | RCH | Pennington | Promoted to active roster | | | Before |
| 8/26/2008 | RCH | Richmond | Signed | | | Before |
| 8/26/2008 | RCH | Riggans | Released | | | Before |
| 8/26/2008 | RCH | Riggans | Promoted to active roster | | | Before |
| 8/26/2008 | RCH | Sweeney,R | Promoted to active roster | | | Before |
| 8/26/2008 | RCH | Wolfe | Released | | | Before |
| 8/26/2008 | WIC | Aceves | Promoted to active roster | | | Before |
| 8/26/2008 | WIC | Gaudin | Promoted to active roster | | | Before |
| 8/26/2008 | WIC | Jackson,E | Promoted to active roster | | | Before |
| 8/26/2008 | WIC | Ramirez,Ed | Promoted to active roster | | | Before |
| 8/26/2008 | WIC | Span | Promoted to active roster | | | Before |
| 8/26/2008 | WIC | Westbrook | Activated from disabled list | | | Before |
| 8/28/2008 | ALX | Choo | Promoted to active roster | | | Before |
| 8/28/2008 | ALX | Drew,J | Demoted to reserve roster | | | Before |
| 8/28/2008 | ALX | Drew,J | Promoted to active roster | | | Before |
| 8/28/2008 | ALX | Matsui,H | Promoted to active roster | | | Before |
| 8/28/2008 | ALX | Okajima | Promoted to active roster | | | Before |
| 8/28/2008 | ALX | Oliver | Promoted to active roster | | | Before |
| 8/28/2008 | ALX | Outman | Promoted to active roster | | | Before |
| 8/28/2008 | ALX | Posada | Promoted to active roster | | | Before |
| 8/28/2008 | ALX | Sherrill | Demoted to reserve roster | | | Before |
| 8/28/2008 | ALX | Zobrist | Promoted to active roster | | | Before |
| 8/28/2008 | BER | Nathan | Demoted to reserve roster | | | Before |
| 9/1/2008 | ALX | Baker,S | Activated from disabled list | | | Before |